Alcor News Bulletin
                Number 44: October 13, 2005


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                      Authors This Issue:

 Jennifer Chapman [JC], Diane Cremeens [DC], Tanya Jones
 [TJ], Mike Perry [MP], Steve Van Sickle [SVS], Website
 Working Group [WWG].


 In this issue:

 *   Financial Matters
 *   M22 Implementation
 *   Whole-Body Engineering Improvement
 *   Very Recent Cryopreservation
 *   Training Matters
 *   Construction Update
 *   Florida and California CryoFeasts
 *   Alcor to Attend Immortality Institute Conference
 *   Hurricane Katrina
 *   Announcing Alcor United
 *   Membership Statistics
 *   Texas CryoFeast
 *   Website Update
 *   Media Update
 *   Employment Opportunities
 *   Next Board Meeting


                      Financial Matters

 The Board appropriation of last month allowed us to catch
 up on almost all current and past due account payables.
 The arrival after the board meeting of further invoices, in
 this case for perfusate components that had been ordered
 previously, totaling about $54,000, means that the
 appropriation did not go as far as was hoped.

 The PCT has been billed for all expenses through the end of
 last month, and the most recent payment had part of the
 amount owed them subtracted. The remaining amount owed
 ($70,000 for two cases) will be subtracted from this
 billing, bringing us current with the PCT.  The CMS fund is
 still owed $22,000, and has been billed for one case.
 Another case that still needs to be billed should cover
 this amount.

 Further upcoming expenses that the appropriation will not
 cover is the $7,000 still owed for perfusate, about $25,000
 in upcoming construction costs not covered by the PCT,
 upcoming attorney fees, and an air conditioning repair that
 may be as much as $9,000. We are not asking for further
 disbursements at this time. [SVS]


                     M22 Implementation

 Alcor has implemented a new whole-body cryopreservation
 procedure which uses a new cryoprotectant solution, M22,
 licensed from 21st Century Medicine. The new cryoprotectant
 is perfused throughout the entire body using the same
 procedures required for glycerol cryoprotection; but while
 it cryoprotects the torso, arms, and legs, we are confident
 that it is also vitrifying the brain. The main difference,
 beyond the composition of the solution, is that
 neurovitrification can be done without separating the brain
 from the rest of the body.

 This new whole-body procedure will now be standard for all
 members currently signed up as whole body, as well as for
 those whole body members who have executed an open option

 The important thing to realize about this process is what
 it cannot do. This is not whole-body vitrification, in the
 sense that the entire body is vitrified. Significant
 portions of the body do not cryoprotect sufficiently to
 vitrify, mostly because things like fatty tissue and
 skeletal muscle are not well-vascularized. This new
 procedure may not be as optimum for brain cryoprotection as
 a simple neuro procedure would be, because of the somewhat
 longer cryoprotection and cooling times. Conversely,
 compromises needed to protect the brain may lead to under-
 cryoprotecting the body, in less ideal cases. But the good
 thing to remember is that brain vitrification is now
 available to those who wish to remain strictly whole-body,
 and that the entire body is cryoprotected intact.

 A significant amount of engineering work was done here at
 Alcor to ensure the proper use of M22. A new circulating
 chiller and perfusion circuit were needed, as were
 controlled-temperature enclosures for both the patient and
 the perfusion circuit to allow safe perfusion at
 temperatures well below the freezing point of water. The
 patient enclosure allows further cooling after
 cryoprotection, to at least -30 or -40 Celsius, reducing
 the hazards of temperature fluctuations while moving the
 patient into the next stage of cooling. The credit for this
 engineering work belongs to Hugh Hixon and Tanya Jones, who
 have done a wonderful job implementing the new procedure.

 Those interested in neurovitrification and whole body
 cryoprotection will no longer have to face the sorts of
 compromises they did in the past, and we believe this is a
 significant advance in our capabilities. For those who
 would like to know more about M22, the composition and
 effects have been published in the scientific literature
 listed below [reference 1]. Electron micrographs of the
 ultrastructure of brain tissue vitrified with M22 have also
 been published [reference 2] and are available on the Alcor
 website at http://alcor.org/Library/html/annals.html.
 Further information and micrographs explaining the switch
 to M22 technology for all Alcor cases can be found on our
 website at

 As explained in reference 1, M22 has been shown to be
 compatible with high viability of tissue slices and with
 consistent survival of kidneys after transplantation. This
 allows the unprecedented vitrification of the human brain
 within the intact human body using a solution that is in
 principle capable of preserving tissue viability as
 measured by present-day methods. However, to be sure that
 the brain will vitrify in compromised human patients, Alcor
 currently must perfuse M22 for longer periods of time than
 those shown to preserve viability in model systems. In
 addition, M22 has not yet been shown to preserve the
 viability of the brain in model system studies.

 Nevertheless, the use of M22 allows Alcor to come closer
 than ever to achieving the goal of in situ brain
 vitrification using perfusion conditions that preserve
 tissue viability by current standards. It keeps Alcor on
 the road to the possible, eventual attainment of this goal.

 (1) Fahy GM, Wowk B, Wu J, Phan J, Rasch C, Chang A,
 Zendejas E. Cryopreservation of organs by vitrification:
 perspectives and recent advances. Cryobiology. (2004)

 (2) Lemler J, Harris SB, Platt C, Huffman TM. The arrest of
 biological time as a bridge to engineered negligible
 senescence. Ann N Y Acad Sci. (2004) Jun;1019:559-63.
 Review. http://alcor.org/Library/html/annals.html


             Whole-Body Engineering Improvement

 As was previously reported, we had a visibility problem
 with the vapor cooling environment for whole-body patients.
 The nitrogen vapor was being circulated around the patient
 with such vigor that the surgeons' vision was obscured. Our
 controls have now been modified so that the three fans
 pushing the vapor through the enclosure can be turned on or
 off individually. The reduction in vapor circulating should
 allow environmental cooling to continue without impairing
 the surgeons' progress. [TJ]


                 Very Recent Cryopreservation

 An Alcor Member in Louisiana deanimated and his
 cryopreservation was started Oct. 11. This brings the Alcor
 patient total to 70. Further details will appear in the
 next Alcor News and in a future issue of Cryonics. [MP]


                      Training Matters

 Our last regional training session for the year was held
 Sept. 24-25 in southern California. The team learned to
 operate their newly-delivered Michigan Instruments Thumper
 (Model 1007). On the completion of the Thumper module, the
 team dove into a transport simulation, which went smoothly.

 I'd like to commend both Bill Voice and all the transport
 team members who participated in the more vigorous training
 program implemented this year for regional groups. Everyone
 has worked hard throughout the course of this year, and the
 improvements in competence and skill are obvious. We'll
 continue the training program next year, and we hope to
 attract more medical professionals, cryonicist volunteers
 and other qualified individuals to the teams. [TJ]


                     Construction Update

 Progress continues on the construction at Alcor. We have
 accepted delivery on the second set of operating room
 lights. More of the extensive electrical and ducting work
 has been completed, and the large door for moving dewars
 has been framed. The new door is ready to be installed.

 A new lab has also been carved out of the existing space
 for Dr. Sheleg. He and Bill Voice worked to create an
 environment for Dr. Sheleg's research that includes
 improved ventilation and air circulation, a surgical
 station, and an operating microscope. Dr. Sheleg has begun
 the projects approved by the Research Committee. [TJ]


              Florida and California CryoFeasts

 In the past month, two CryoFeasts were held and attended by
 several Alcor staff members. Both of these events were well
 attended by the general public and Alcor members. We spent
 a fair amount of time responding to questions on the
 deployment of the transport vehicle and whole-body partial
 vitrification system. Even the prospective members at these
 events were excited. We hope to capitalize on the interest
 in the months to come and have already received multiple
 applications from the Florida event. [TJ]


      Alcor to Attend Immortality Institute Conference

 You are invited to join Steve Van Sickle, Executive
 Director, and Tanya Jones, Director of Technical Operations
 at the Immortality Institute Conference on November 5,
 2005, in Atlanta. Enjoy this rare opportunity to listen to
 their comments about cryonics in a panel discussion. [JC]


                      Hurricane Katrina

 Anyone affected by Hurricane Katrina is urged to contact
 Alcor. We need your current contact info and want to ensure
 you are in a safe area that is accessible by aircraft. [TJ]


                   Announcing Alcor United

 Alcor members have a new forum where they can meet and chat
 with other members. Please visit Alcor United
 (www.alcorunited.org), an Internet forum for Alcor members
 created and moderated by James Conaway, a nine-year member
 of Alcor. Conaway says, "I have two main goals for the
 forum. (1) Create an easy-to-reach meeting place for Alcor
 members to share experiences, thoughts and ideas. (2)
 Introduce the world and potential new members to Alcor's
 community and culture. The forum is a community building
 project. The categories of discussion range from philosophy
 and technology to general questions about cryonics and
 Alcor. Users are required to register to post in the
 majority of the forums, but I have added an anonymous forum
 for those who wish to remain anonymous."

 Conaway felt a need recently to talk with other Alcor
 members and could not find an easy way to do so. He has
 attended Alcor events and knows we have a large group of
 good people. Alcor United creates a new opportunity for
 members to connect with each other and strengthen our
 community. [Submitted by James Conaway/JC]



                    Membership Statistics

 On September 30, 2005, Alcor had 773 members on its
 Emergency Responsibility List.  One membership was approved
 during this month, one membership was reinstated, and two
 memberships were cancelled.  Overall, there was a net gain
 of zero members this month.  We have an average net gain of
 6.7 members per month in 2005, which compares favorably to
 the average net gain of 4.3 members per month last year.

 At the end of this month, Alcor had 68 applicants for
 membership. With twelve incoming applicants, one membership
 approval, and two people withdrawing from the application
 process, there was a net gain of nine applicants.

 During the month of September, 183 information packs were
 distributed. Of those, 176 were mailed, and 6 were handed
 to facility tour participants. Our average for 2005 has
 grown to 111 per month, compared to 50 in 2004. There were
 775 subscribers to Alcor News as of the September issue.


                       Texas CryoFeast

 Natasha Vita-More is hosting the San Antonio, Texas,
 CryoFeast on November 12.  Texas members and applicants,
 watch for your invitation in the mail soon! [JC]


                        Website Update

 An estimated 25,514 distinct computers visited Alcor's
 website in September. There was a small access spike on
 Sept. 5 coincident with the New York Times article on the
 Ted Williams "death mask" art exhibit. There was a large
 access spike (triple normal traffic) on Sept. 15, the same
 day that an Israeli company announced success freezing
 sheep ovaries. [WWG]


                         Media Update

 - FuJi TV:  This crew did a 15-minute spot about Alcor on a
 news program that is similar to 20/20.

 - Red Back Films: This crew is doing a one-hour documentary
 about therapeutic hypothermia and cryonics as a logical
 extension of treatments involving reduced body temperature.
 It will air on Channel 4 in the UK and The Learning Channel
 in the US in spring of 2006.

 - Zig Zag Productions:  Alcor signed an Exclusivity
 Agreement with this UK production company licensing them
 exclusive rights for up to 12 months of footage of a yet-
 to-be-filmed cryopreservation case. The film crew will be
 headed by Deb Johnson of WalshCOMM and the footage will be
 Alcor's property, with Alcor given full editorial control
 prior to releasing the footage to Zig Zag.

 - Alcor declined to participate in another reality-based TV
 series program.

 - The Arizona Capital Times published Alcor's response to
 an editorial letter written by Jack Polidoro, a fiction
 writer from New Hampshire. Polidoro's original letter,
 "Rep. Stump Deserves Praise For Efforts To Oversee Cryonics

 Alcor's response, "Letter writer off the mark; Alcor has
 stringent financial oversight":


                   Employment Opportunities

 Have you ever thought about joining the Alcor team? We have
 immediate needs for licensed Paramedics, Emergency Medical
 Technicians, Registered Nurses, Lab Technicians and more to
 join our nationwide Transport Team. Participation would be
 on a contractual basis.

 You'll be given cryonics training that will enable you to
 participate in our patient rescue and transport cases.
 Licensed professionals do not have to be Alcor members to
 work with us. We welcome your expertise and interest. If
 you're interested, send your resume to:


                     Next Board Meeting

 The next Board meeting is scheduled for Saturday, November
 12, 2005, at 11:00 AM (MST).

 Board meetings are typically held on the first Saturday of
 the month at the Alcor facility (7895 East Acoma Drive in
 Scottsdale, AZ). Members and the public are encouraged to


 End of Alcor News bulletin #44 dated October 13, 2005.
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